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Ann. Oncol. 393 Index Forrest Committee Optiobs 112 TRAM Xap 26, 2012 timing 245 see also mastectomy; reconstructive surgery systemic therapy see adjuvant systemic therapy; chemotherapy tamoxifen UUp adjuvant 1635 adverse eVects 458, 166 bone density and fractures 48 cardiovascular disease 478 endometrial cancer 467, 1667 genotoxicity 50 menopausal symptoms and anxiety 456 ocular eVects 47 vascular events 46 antagonism between tamoxifen and HRT 901 chemoprevention trials 3955 adverse eVects 458 dose ranges 501 overview 435 future developments 11721 general principles 1047, 105 National Screening Programme organizational aspects ovarian cancer 67 process 113 purpose 1034 quality assurance targets randomized controlled trials sensitivityspeciWcity SECRAB study 199 sedation 3812 selenium-dependent glutathione peroxidases (GSHPx) 248 sentinel node biopsy, axillary surgery SERMs 2867 alternatives to HRT 778 chemoprevention of breast cancer see also raloxifene; tamoxifen; toremifene serotonin-uptake inhibitors 75 serous eVusions 301 simvastatin, cardioprotective lipid-lowering eVect 77 skin metastases 3778 soy phyto-oestrogens 534, 756 spinal cord compression 375 START study 1968 steroid receptors clinical trials DCIS 1323 expression, scoring system see also speciWc named receptors see also EBCTCG duration 1656 elimination by tumour cells 231 ER-negative tumours 236 ethnic groups 49 Italian Tamoxifen Prevention Study 41, 423 node-negative, receptor-positive breast cancer 169 and oestradiol (serum) 81 primary medical therapy 275 vs.

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